Slower disease progression and prolonged survival in contemporary patients with amyotrophic lateral sclerosis.
نویسندگان
چکیده
Design: By using the Kaplan-Meier life-table method, we compared disease progression (measured as time to a 20-point increase in the Appel ALS score) and survival in 1041 patients diagnosed as having ALS between January 1, 1984, and January 1, 1999 (historical group, n=647), and between January 2, 1999, and November 1, 2004 (contemporary group, n=394). The Cox proportional hazards model was used for univariate and multivariate analyses.
منابع مشابه
Slower disease progression and prolonged survival in contemporary patients with amyotrophic lateral sclerosis: is the natural history of amyotrophic lateral sclerosis changing?
BACKGROUND In recent years, considerable effort has been made to improve the treatment of patients with amyotrophic lateral sclerosis (ALS). However, despite the increased use of supportive measures, controversy still exists about overall trends in disease progression and survival. OBJECTIVE To analyze whether survival and disease progression in patients with ALS have changed during the past ...
متن کاملEvaluation of the effectiveness of positive psychology-based interventions on post-traumatic growth, self-compassion and quality of life in patients with amyotrophic lateral sclerosis (ALS)
Introduction: Amyotrophic lateral sclerosis (ALS) is a relatively rare disease that can be associated with various mental, physical and psychological burdens. The aim of this study was to evaluate the effectiveness of interventions based on positive psychology on post-traumatic growth, self-compassion and quality of life in patients with amyotrophic lateral sclerosis. Methods: This descriptive-...
متن کاملEvaluation of Pulmonary Function Test in Patients with Amyotrophic lateral sclerosis and its correlation with the symptoms of the disease
Introduction: Amyotrophic lateral sclerosis (ALS) is a neurogenic progressive disease that leads to muscle atrophy. The purpose of this study was to evaluate pulmonary function test (PFT) in patients with ALS and its correlation with ASL symptoms. Materials and Methods: This cross-sectional study was performed on 32 ALS patients at Ghaem Hospital, Mashhad...
متن کاملAmyotrophic Lateral Sclerosis in a Patient with Behçet’s Disease
Behçet’s disease is a multisystem vasculitis. Its neurological involvement mostly includes parenchymal and non-parenchymal central nervous system manifestations. Peripheral nervous system presentations are rare. A 32-yr-old male patient who fulfilled the international study group criteria for Behçet’s disease, referred to our center with walking difficulty and repeated falling downs. Neurologi...
متن کاملEndogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is a relentless and devastating adult-onset neurodegenerative disease with no known cure. In mice with amyotrophic lateral sclerosis, CD4+ T lymphocytes and wild-type microglia potentiate protective inflammatory responses and play a principal role in disease pathoprogression. Using this model, we demonstrate that endogenous T lymphocytes, and more specifically regu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Archives of neurology
دوره 64 3 شماره
صفحات -
تاریخ انتشار 2007